Hyperbaric Oxygen Therapy for Non-Healing Wounds: Mechanisms and Outcomes

Non-healing wounds, such as diabetic ulcers, venous stasis ulcers, or wounds from radiation therapy, present significant challenges in medical care. These wounds are characterized by their failure to progress through the normal stages of healing, often due to underlying conditions that impair blood flow, oxygenation, and nutrient delivery to the wound site. Hyperbaric Oxygen Therapy (HBOT) has emerged as a vital adjunctive treatment for non-healing wounds, leveraging the healing power of oxygen to improve outcomes. At Revivo, our approach to wound care integrates advanced therapies like HBOT to enhance healing processes. This post explores the mechanisms by which HBOT facilitates wound healing and the outcomes it can achieve.

HBOT Mechanisms in Wound Healing

Increased Oxygenation: HBOT dramatically increases the partial pressure of oxygen in the blood, allowing greater oxygen delivery to tissues, including areas with compromised circulation. Oxygen is a critical factor in wound healing, essential for cellular functions such as energy production, bacterial defense, and tissue repair.

Stimulation of Angiogenesis: Chronic wounds often suffer from inadequate blood supply. HBOT can stimulate the formation of new blood vessels (angiogenesis) in and around the wound, improving blood flow and oxygen delivery, which are essential for wound healing.

Enhanced Fibroblast Activation: Fibroblasts play a crucial role in wound healing by producing collagen, which forms the foundation of the repair process. HBOT has been shown to stimulate fibroblast activity, resulting in more robust and faster tissue repair.

Reduction of Edema and Inflammation: HBOT can help reduce swelling and inflammation around the wound. By decreasing edema, HBOT improves blood flow to the area, facilitating the removal of debris and inflammatory mediators, which can otherwise impede healing.

Antimicrobial Effects: The high levels of oxygen delivered during HBOT sessions possess antimicrobial properties, helping to reduce the bacterial load in and around the wound. This is particularly beneficial for wounds at risk of or already suffering from infection.

Outcomes of HBOT for Non-Healing Wounds

Accelerated Healing Rates: Numerous studies have demonstrated that HBOT can accelerate the healing process of non-healing wounds, leading to faster closure rates compared to standard wound care treatments alone.

Reduced Amputation Rates: For diabetic foot ulcers, in particular, HBOT has been associated with a significant reduction in amputation rates. By enhancing wound healing and reducing infections, HBOT can help save limbs that might otherwise be lost.

Improved Quality of Life: Faster wound healing and the avoidance of amputations contribute to significantly improved quality of life for patients. Moreover, the reduction in wound-related complications decreases the overall burden on patients and healthcare systems.

Cost-Effectiveness: While the upfront costs of HBOT can be high, the long-term savings from avoided surgeries, amputations, and reduced hospital stays make HBOT a cost-effective option for managing non-healing wounds.

Integrating HBOT into Wound Care

At Revivo, HBOT is considered part of a comprehensive wound care strategy that includes infection control, debridement, proper nutrition, and moisture balance. Personalized treatment plans ensure that HBOT is used optimally, alongside conventional therapies, to address the specific needs of each patient.


Hyperbaric Oxygen Therapy offers a promising adjunctive treatment for non-healing wounds, addressing the underlying issues of oxygenation and blood flow that hinder the healing process. By understanding the mechanisms and outcomes associated with HBOT, patients and healthcare providers can better navigate the options available for wound care. At Revivo, we are committed to incorporating advanced therapies like HBOT into our practice, aiming to improve healing outcomes and enhance the quality of life for our patients facing the challenges of non-healing wounds.

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