Hyperbaric Oxygen Therapy as an Adjunctive Treatment in Cancer Care

Hyperbaric Oxygen Therapy (HBOT) has garnered attention as a potential adjunctive treatment in the comprehensive care of cancer patients. HBOT involves breathing 100% oxygen at elevated pressures within a hyperbaric chamber, leading to increased oxygen delivery to tissues throughout the body. While the primary use of HBOT in cancer care has historically focused on managing side effects of conventional treatments, emerging research suggests it may also have direct and indirect benefits for cancer patients. At Revivo, we are committed to exploring all avenues of care that could enhance the well-being and recovery of our patients, including the integration of HBOT in cancer treatment protocols.

HBOT and Radiation Therapy Side Effects

One of the well-documented applications of HBOT in cancer care is in the treatment of radiation-induced injuries, such as osteoradionecrosis, soft tissue radionecrosis, and radiation cystitis. These conditions can arise as late effects of radiation therapy, leading to significant discomfort and impairment.

  • Osteoradionecrosis: HBOT can stimulate angiogenesis (the formation of new blood vessels) and fibroblast proliferation, enhancing bone regeneration and healing.
  • Soft Tissue Radionecrosis: Increased oxygenation can improve wound healing in damaged soft tissues, reducing pain and inflammation.
  • Radiation Cystitis: For bladder injuries, HBOT has shown promise in reducing symptoms like hematuria (blood in urine), urgency, and pain.

Research on HBOT’s Anti-Tumor Effects

Emerging research has begun to explore the potential anti-tumor effects of HBOT. Some studies suggest that the high oxygen levels could inhibit the growth of certain types of cancer cells or make them more susceptible to radiation and chemotherapy. However, it’s important to note that this research is still in its early stages, and more studies are needed to fully understand HBOT’s role in direct cancer treatment.

Enhancing Chemotherapy Efficacy

There is interest in HBOT’s potential to enhance the efficacy of certain chemotherapy agents. The rationale is that increased oxygen levels may improve the sensitivity of hypoxic (low oxygen) tumor cells to chemotherapy. While promising, this application of HBOT in cancer care requires further clinical evidence to establish its effectiveness and safety fully.

Considerations and Cautions

While HBOT offers potential benefits in cancer care, it’s crucial to approach its use judiciously, especially as an adjunctive treatment. Key considerations include:

  • Personalized Treatment Planning: Decisions regarding HBOT should be made on an individual basis, considering the patient’s overall treatment plan, type of cancer, and response to conventional therapies.
  • Timing and Dosage: The timing, duration, and pressure of HBOT sessions need careful consideration to maximize benefits and minimize risks.
  • Potential Risks: As with any medical treatment, HBOT comes with potential side effects, such as ear barotrauma, sinus discomfort, and, rarely, oxygen toxicity. These risks must be weighed against the potential benefits in the context of cancer care.

The Future of HBOT in Cancer Treatment

As research into the applications of HBOT in cancer care continues, we may see more refined protocols for its use as an adjunctive treatment. Ongoing clinical trials and studies will be crucial in determining the efficacy of HBOT in improving cancer treatment outcomes, reducing side effects, and enhancing patient quality of life.


Hyperbaric Oxygen Therapy presents an intriguing adjunctive treatment option in cancer care, with potential applications ranging from mitigating the side effects of radiation therapy to enhancing the efficacy of chemotherapy. At Revivo, our approach to cancer care is holistic and patient-centered, always seeking to integrate the most effective, evidence-based treatments to support our patients’ journeys. As the research landscape evolves, we remain committed to incorporating innovative therapies like HBOT that can offer meaningful benefits to those facing cancer.

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